The EspF effector – a bacterial pathogen ’ s
نویسندگان
چکیده
10 Central to the pathogenesis of many bacterial pathogens is the ability to deliver effector 11 proteins directly into the cells of their eukaryotic host. EspF is one of many effector proteins 12 exclusive to the attaching and effacing pathogen family that includes enteropathogenic 13 (EPEC) and enterohemorrhagic E. coli (EHEC). Work in recent years has revealed EspF to be 14 one of the most multi-functional effector proteins known, with defined roles in several host 15 cellular processes including disruption of the epithelial barrier, anti-phagocytosis, microvilli 16 effacement, host membrane remodelling, modulation of the cytoskeleton, targeting and 17 disruption of the nucleolus, intermediate filament disruption, cell invasion, mitochondrial 18 dysfunction, apoptosis and the inhibition of several important epithelial transporters. 19 Surprisingly, despite this high number of functions, EspF is a relatively small effector protein 20 and recent work has begun to decipher the molecular events that underlie its multi21 functionality. This review focuses on the activities of EspF within the host cell and discusses 22 Copyright © 2010, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Infect. Immun. doi:10.1128/IAI.00635-10 IAI Accepts, published online ahead of print on 2 August 2010 on N ovem er 1, 2017 by gest http/iai.asm .rg/ D ow nladed fom
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